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11 May 2017 Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells
Danupon Nantajit, Suwimol Jetawattana, Tawit Suriyo, David J. Grdina, Jutamaad Satayavivad
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Abstract

One of the most concerning side effects of exposure to radiation are the carcinogenic risks. To reduce the negative effects of radiation, both cytoprotective and radioprotective agents have been developed. However, little is known regarding their potential for suppressing carcinogenesis. Andrographis paniculata, a plant, with multiple medicinal uses that is commonly used in traditional medicine, has three major constituents known to have cellular antioxidant activity: andrographolide (AP1); 14-deoxy-11,12-didehydroandrographolide (AP3); and neoandrographolide (AP4). In our study, we tested these elements for their radioprotective properties as well as their anti-neoplastic effects on transformation using the BALB/3T3 cell model. All three compounds were able to reduce radiation-induced DNA damage. However, AP4 appeared to have superior radioprotective properties compared to the other two compounds, presumably by protecting mitochondrial function. The compound was able to suppress radiation-induced cellular transformation through inhibition of STAT3. Treatment with AP4 also reduced expressions of MMP-2 and MMP-9. These results suggest that AP4 could be further studied and developed into an anti-transformation/carcinogenic drug as well as a radioprotective agent.

©2017 by Radiation Research Society.
Danupon Nantajit, Suwimol Jetawattana, Tawit Suriyo, David J. Grdina, and Jutamaad Satayavivad " Andrographis paniculata Diterpenoids Protect against Radiation-Induced Transformation in BALB/3T3 Cells," Radiation Research 188(1), 66-74, (11 May 2017). https://doi.org/10.1667/RR14698.1
Received: 28 November 2016; Accepted: 1 March 2017; Published: 11 May 2017
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