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21 May 2018 Significant Suppression of CT Radiation-Induced DNA Damage in Normal Human Cells by the PrC-210 Radioprotector
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Abstract

While computed tomography (CT) is now commonly used and considered to be clinically valuable, significant DNA double-strand breaks (γ-H2AX foci) in white blood cells from adult and pediatric CT patients have been frequently reported. In this study to determine whether γ-H2AX foci and X-ray-induced naked DNA damage are suppressed by administration of the PrC-210 radioprotector, human blood samples were irradiated in a CT scanner at 50–150 mGy with or without PrC-210, and γ-H2AX foci were scored. X-ray-induced naked DNA damage was also studied, and the DNA protective efficacy of PrC-210 was compared against 12 other common “antioxidants.” PrC-210 reduced CT radiation-induced γ-H2AX foci in white blood cells to near background (P < 0.0001) at radiation doses of 50–150 mGy. PrC-210 was most effective among the 13 “antioxidants” in reducing naked DNA X-ray damage, and its addition at 30 s before an OH pulse reduced to background the OH insult that otherwise induced >95% DNA damage. A systemic PrC-210 dose known to confer 100% survival in irradiated mice had no discernible effect on micro-CT image signal-to-noise ratio and CT image integrity. PrC-210 suppressed DNA damage to background or near background in each of these assay systems, thus supporting its development as a radioprotector for humans in multiple radiation exposure settings.

©2018 by Radiation Research Society.
Frank Jermusek Jr., Chelsea Benedict, Emma Dreischmeier, Michael Brand, Michael Uder, Justin J. Jeffery, Frank N. Ranallo, and William E. Fahl "Significant Suppression of CT Radiation-Induced DNA Damage in Normal Human Cells by the PrC-210 Radioprotector," Radiation Research 190(2), 133-141, (21 May 2018). https://doi.org/10.1667/RR14928.1
Received: 2 September 2017; Accepted: 2 April 2018; Published: 21 May 2018
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