From January to May 2008, the first historical strandings of Peponocephala electra Gray (Melon-headed Whale) and Lagenorhynchus acutus Gray (Atlantic White-sided Dolphin) were recorded in South Carolina. A mass stranding of three Melon-headed Whales (2 males, 1 female) was recorded on 11 January 2008 along the Horry County coast in the cities of Myrtle Beach and North Myrtle Beach. Three additional Melon-headed Whales (1 male, 1 female, and 1 unknown sex) stranded as single individuals over the next two months at locations along the South Carolina coast. Lengths of the animals ranged from 161 to 250 cm, and the ages ranged from 1 to 24 years. On 4 May 2008, a single 263cm, 17-year-old, male Atlantic White-sided Dolphin stranded in Horry County. The most striking commonalities observed during the Melon-headed Whale and Atlantic White-sided Dolphin necropsies were severe pulmonary distress and reactive lymphadenopathy. The strandings reported herein are the first records of Melon-headed Whales and Atlantic White-sided Dolphins in South Carolina.