Maps of wild or roadless areas in North America show that most lie west of the Mississippi River. The Everglades is one exception. Yet there are others. Using existing data, I draw attention to four large areas in the southeast that are worthy of national as well as regional attention. These four (Eglin: 187,000 ha; Apalachicola: 228,000 ha; Okefenokee-Oceola: 289,000 ha; De Soto: 200,000 ha) have nearby lands that offer the potential to expand the total protected territory for each area to well beyond 500,000 ha. From the North American perspective, these areas are essential elements of a national conservation plan. These areas urgently need (1) land acquisition to link with nearby protected lands and establish ecologically meaningful boundaries, (2) restoration of natural forces (particularly flooding and fire), and (3) forestry practices focused upon restoration.