During the preparation of the Euphorbiaceae taxonomic treatment for the Chapada dos Veadeiros National Park, located in the state of Goiás, Brazil, we found a new species of Manihot. Manihot saxatilis is described and illustrated here. The morphological relationship of this species is discussed in comparison with M. stricta Baill., since we assume this species is the most morphologically similar to the new one. Based on morphological traits, the new species belongs to Manihot sect. Brevipetiolatae. The distribution, habitat, phenology, etymology, IUCN red list category, and a key to all species of Manihot sect. Brevipetiolatae are also provided.