In this paper we propose a new circumscription of Aniseia that includes Iseia and reduces Aniseia martinicensis var. ambigua and A. cernua to the synonymy of A. martinicensis. The new combination Aniseia luxurians is made. The three species of Aniseia recognized herein are characterized by simple trichomes; simple leaves with entire margin, mucronate apex and eucamptodromous venation; axillary cymose inflorescences, or solitary flowers; unequal to subequal sepals; campanulate corolla; single style; glandular trichomes at bases of filaments, sagittate anthers, and 2-globose and papillose stigma. Furthermore, twelve new synonyms and eleven lectotypifications are proposed herein. We provide an identification key, illustrations, comments on geographical distribution, and specimen-based distribution maps, as well as taxonomic and nomenclatural information.