A new species of Annonaceae endemic to Mexico, namely Desmopsis duran, is described and illustrated. This new species is placed within the Desmopsis-Stenanona clade and is clearly different from any other species of Desmopsis by the combination of elliptic to narrowly elliptic leaves, terminal and branch-like inflorescences, and long pedicellate flowers with six or eight petals. Its morphology and phylogenetic relationships are discussed.