Translator Disclaimer
1 August 2014 Drug-Resistant Tuberculosis: A Genetic Analysis using Online Bioinformatics Tools
Author Affiliations +
Abstract

Tuberculosis (TB) continues to be a serious global health problem, resulting in >1.4 million deaths each year. Of increasing concern is the evolution of antibiotic-resistant strains of the bacterium that causes TB. Using this real-world scenario, we created a 90-minute activity for high school or undergraduate students to use online bioinformatics tools to detect single-nucleotide polymorphisms (SNPs) between a wild-type and a variant Mycobacterium tuberculosis gene that could confer resistance to a commonly used TB antibiotic, rifampin. Students write a scientific explanation, providing evidence and reasoning, to support their claim of antibiotic resistance or susceptibility. The entire lesson can be found online at  http://www.stronglab.org/taylor.

©2014 by National Association of Biology Teachers. All rights reserved. Request permission to photocopy or reproduce article content at the University of California Press's Rights and Permissions Web site at www.ucpressjoumals.com/reprintinfo.asp.
Jessica M. Taylor, Rebecca M. Davidson, and Michael Strong "Drug-Resistant Tuberculosis: A Genetic Analysis using Online Bioinformatics Tools," The American Biology Teacher 76(6), 386-394, (1 August 2014). https://doi.org/10.1525/abt.2014.76.6.6
Published: 1 August 2014
JOURNAL ARTICLE
9 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top