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1 August 2014 Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques
Bethany Bowling, Erin Zimmer, Robert E. Pyatt
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Abstract

Although the development of next-generation (NextGen) sequencing technologies has revolutionized genomic research and medicine, the incorporation of these topics into the classroom is challenging, given an implied high degree of technical complexity. We developed an easy-to-implement, interactive classroom activity investigating the similarities and differences between current sequencing methodology and three NextGen technologies. The activity uses existing materials created by each of the biotechnology companies that outline their instrumentation and chemistries. Following this activity, students will understand the molecular biology behind these NextGen applications and the similarities to existing Sanger sequencing methods.

©2014 by National Association of Biology Teachers. All rights reserved. Request permission to photocopy or reproduce article content at the University of California Press's Rights and Permissions Web site at www.ucpressjoumals.com/reprintinfo.asp.
Bethany Bowling, Erin Zimmer, and Robert E. Pyatt "Bringing Next-Generation Sequencing into the Classroom through a Comparison of Molecular Biology Techniques," The American Biology Teacher 76(6), 396-401, (1 August 2014). https://doi.org/10.1525/abt.2014.76.6.7
Published: 1 August 2014
JOURNAL ARTICLE
6 PAGES

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KEYWORDS
molecular biology
next-generation sequencing
Sanger sequencing
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