The AAAS “Vision and Change” report (2011) has been inspiring undergraduate biology educators nationwide to rethink their educational approach, favoring active-learning strategies to better prepare today's students for a complex, data-rich future. Here, we consider the history of the movement, its place in the greater arena of STEM education, and the reasons why this new approach has never been more critical. We encourage all biology educators to consider becoming agents of change, and we focus on helpful resources and practical suggestions to help ABT readers take the plunge into (or at least get their feet wet in) the welcoming waters of Vision and Change.