In an earlier paper (Smith & Baldwin, 2015), we explained the basic concepts of the Hardy-Weinberg equilibrium (HWeq) principle needed for meaningful understanding and for good teaching, emphasizing distinctions that are sometimes ignored at the cost of coherent understanding, and identifying nine shortcomings of most available Hardy-Weinberg activities and problem sets. In the present paper, we provide a 5E lesson plan based on that analysis and designed to avoid the shortcomings identified, including providing original data and focusing on understanding and topics that are interesting and meaningful to young people.