In this article, we put forward a new approach to the teaching of scientific reasoning in biology with the Next Generation Science Standards (NGSS). We argue that a framework based on the idea of six styles of scientific reasoning provides the best guide for biology teachers to the nature of scientific reasoning in biology and how it might be taught. The current framework of the crosscutting concepts fails to provide a narrative for what makes biology distinctive and how biological scientists reason. By contrast, a framework of styles of scientific reasoning does offer a coherent argument for the biology curriculum in grades K–12, a justification for each performance expectation, and a vision of how each standard might support the development of scientific reasoning in biology. Examples and implications for curriculum designers and educators are discussed.