A solid understanding of the chemical properties of bonds, functional groups, and molecules is an essential component of general biology. Students often struggle to connect these concepts and apply them appropriately. Manipulatives provide a concrete tool for visualizing these concepts and allow the instructor to see (literally) what students do not understand. Here, we present a manipulatives-based exercise that reinforces student understanding and application of the properties of hydrocarbons, functional groups, carbohydrates, proteins, and lipids. The exercise also explores how functional groups contribute to the shape and properties of different classes of biomolecules. The structure of this activity helps both instructors and students identify misconceptions and provides an opportunity to resolve them through peer learning, modeling, and individual attention from the instructor.