Published reports of survival and cause-specific mortality for pronghorn (Antilocapra americana) indicate that mortality differs regionally and seasonally with sex, age and density of pronghorn. Cold winters with deep crusted snow is a primary source of mortality on adult pronghorn, however, predation also can be an important source of adult mortality. We report a visual observation of bobcat (Felis rufus) predation on an adult female pronghorn in northwestern South Dakota.