Translator Disclaimer
1 July 2002 In Vitro Leishmanicidal Activity of a Monoclonal Antibody mimicking a Yeast Killer Toxin
Author Affiliations +
Abstract

The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose-dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype-matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.

DIANELLA SAVOIA, CLAUDIO AVANZINI, STEFANIA CONTI, VALTER MAGLIANI, RAFFAELE FRAZZI, and LUCIANO POLONELLI "In Vitro Leishmanicidal Activity of a Monoclonal Antibody mimicking a Yeast Killer Toxin," The Journal of Eukaryotic Microbiology 49(4), 319-323, (1 July 2002). https://doi.org/10.1111/j.1550-7408.2002.tb00377.x
Received: 19 November 2001; Accepted: 2 April 2002; Published: 1 July 2002
JOURNAL ARTICLE
5 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top