This paper provides distributional and biological notes for 43 species and subspecies of North American Meloidae in the genera Epicauta Dejean, 1834, Eupompha LeConte, 1858, Gnathium Kirby, 1818, Linsleya MacSwain, 1951, Lytta Fabricius, 1775, Meloe Linnaeus, 1758, Nemognatha Illiger, 1807, Pleuropasta Wellman, 1909, Pseudozonitis Dillon, 1952, Pyrota Dejean, 1834, Rhyphonemognatha Enns, 1956, Spastonyx Selander, 1954, and Zonitis Fabricius, 1775. These include 22 new state records, 19 new hosts, and numerous range extensions.