The genus Cycleptus is widely distributed in the Mississippi, Missouri, and Ohio rivers and in Gulf-slope drainages, including the Rio Grande. Recent genetic evidence suggests that Cycleptus in the Rio Grande is an undescribed species; however, there are few specimens from Mexico. These include two records from the Río Conchos, two from the Rio Grande and another from the Río Salado. In 1954, Cycleptus was reported in two localities in the Río Conchos: 1.6 km N Saucillo and 1 km above the confluence of the Rio Grande and the Río Conchos. After a purported absence of 51 years, it has been rediscovered in three localities in the state of Chihuahua: the mouth of the Río Conchos at Rio Grande, Cuchillo Parado, and Río Conchos at El Alamo.