The antelope jackrabbit (Lepus alleni) is a lagomorph indicative of Neotropic savanna and thornscrub in south-central Arizona, west-central Sonora, and western Sinaloa <1,200 m elevation. We found populations in Arizona are most abundant in tropic–subtropic areas of low relief, characterized by velvet mesquite (Prosopis velutina) with an herbaceous understory (= Sonoran savanna grassland), and receiving a mean annual rainfall of between 200 and 450 mm, >90 mm of which falls as summer precipitation. In Mexico, this hare most commonly occurred in savanna grasslands or thornscrub interrupted by open areas receiving between 200 and 450 mm of precipitation per annum. Cacti were important habitat components for the hares and mean annual temperatures were >18°C with <60 d a year having temperatures below 0°C. Although sympatric with Lepus californicus over portions of its range, the two species preferred different habitats and rarely occurred together, and L. alleni was more prone to occur in groups than was L. californicus. We calculated the distributional range of L. alleni as ca. 102,000 km² in Arizona and Mexico.