We develop a 341-year Oregon white oak (Quercus garryana Dougl.) tree-ring chronology in Oregon's Willamette Valley to evaluate climate-growth relationships and determine the species' dendroclimatological potential at our site and in the surrounding region. The standardized and residual chronologies exhibit significant positive correlations with previous-year April and May temperatures, inverse correlations with previous-year spring precipitation and summer PDSI, a positive correlation with current-year July precipitation and summer PDSI, and inverse correlations with current-year June temperatures. The strength of these relationships varies over time. Significant shifts in the chronologies' mean and variance align with phase changes in the Pacific Decadal Oscillation (PDO), with lower and more variable growth during the warmer, drier positive phase of the PDO over the instrumental record. The absence of similar shifts prior to the 1900s, suggests a lack of temporal consistency in the expression of PDO variability at our site. The strong crossdating at our site reflects a cohesive climate signal, and the climate analysis illustrates the potential to develop proxy data over multiple centuries. Together, these results indicate a potential to expand the network of currently available climate proxy data by utilizing Q. garryana in dendroclimatological research.