The hispid pocket mouse (Chaetodipus hispidus) occurs throughout the Great Plains, mainly west of the Missouri River. In Nebraska, this species likely occurs throughout the state, but records of occurrence were lacking for east-central and northeastern counties. During a survey in 2008 for the plains pocket mouse (Perognathus flavescens) in eastern Nebraska, we documented C. hispidus in 10 new counties, including a modest range expansion into northeastern Nebraska. Many individuals were captured on moderately compact soils consisting of silt, but some also were captured on sandy and other friable soils. Most individuals were captured in areas containing some exposed ground, but this may reflect our trap placement for P. flavescens. Individuals from northeastern and east-central Nebraska best resembled C. h. spilotus from southeastern Nebraska, with black coloration suffused on the dorsum, head, and dorsal side of the tail; however, our individuals generally lacked the characteristic bright ochraceous coloration along lateral lines and on the dorsum. Limited evidence supports a recent expansion in distribution within the region.