We report, for the first time, visitation to the inflorescences of the endemic Agave cupreata by 2 marsupial species, Didelphis virginiana and Tlacuatzin canescens, in the state of Michoacán, western Mexico. These 2 species were recorded drinking the nectar of A. cupreata and transporting large amounts of pollen among the flowers. This agave is restricted to the mountainous slopes of the Balsas River basin in the states of Michoacán and Guerrero, and it constitutes the raw material for local production of a traditional beverage known as mezcal. In contrast to many other agaves that can propagate vegetatively, A. cupreata only reproduces sexually and has low self-fertilization capacity. Thus, the visits of the marsupials, while infrequent compared to those of bats and birds, could provide an important pollination service given the quantity of pollen that was moved and the duration of their visits. In addition, these 2 marsupial species are able to persist in transformed landscapes, raising the possibility that they could compensate for the loss of other vertebrate pollinators of A. cupreata that are more sensitive to habitat disruption.