Predation by jaguars (Panthera onca) on livestock can foster human intolerance and drive human–jaguar conflicts. Understanding distributional patterns that characterize depredation can help guide strategies to ameliorate these interactions, which is important because human conflicts are the main threat to the endangered jaguar in Mexico. We used clusters of satellite telemetry locations to evaluate spatial patterns of jaguars and jaguar predation/scavenging sites of livestock and wild ungulates in the Sierra del Abra-Tanchipa Biosphere Reserve (RBSAT) and surrounding agrolandscape of northeastern Mexico, where livestock composed 66% of the biomass of jaguar diets. Distribution of livestock sites was significantly associated with jaguar core areas (i.e., 50% autocorrelated KDEs) during the dry season, while wild ungulate sites were distributed similarly with respect to core areas of jaguars across both dry and wet seasons. It is unknown whether these results reflect increased chance encounters between jaguars and livestock during the dry season due to the presence of limited permanent water sources concentrating livestock (and natural prey), or due to jaguars actively seeking livestock or livestock carcasses during the dry season.