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1 March 2012 Changes in Thyroid Hormone Levels during Zebrafish Development
Juhua Chang, Minghua Wang, Wenjun Gui, Ying Zhao, Liang Yu, Guonian Zhu
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Abstract

The zebrafish (Danio rerio) has been used as a model for the study of endocrine disrupting chemicals. This study set out to determine the profiles of whole-body thyroxine (T4) and 3,5,3'-triiodothyronine (T3) levels during the development of zebrafish from embryo to adult. Enzyme-linked immunoassay was used to analyze whole-body T4 and T3 contents. The results showed that whole-body T4 and T3 levels remained stable during the pre-hatching period (0–3 d) and increased significantly during early development after hatching. The T3 level peaked at 0.28 ± 0.01 ng g-1 body weight at 10 days post-fertilization (dpf), and T4 peaked at 0.58 ± 0.09 ng g-1 body weight at 21 dpf. Both thyroid hormones subsequently declined during later development. This study establishes a baseline for thyroid hormones in zebrafish, which will be vital for the understanding of thyroid hormone functions and in future studies of thyroid toxicants in this species.

© 2012 Zoological Society of Japan
Juhua Chang, Minghua Wang, Wenjun Gui, Ying Zhao, Liang Yu, and Guonian Zhu "Changes in Thyroid Hormone Levels during Zebrafish Development," Zoological Science 29(3), 181-184, (1 March 2012). https://doi.org/10.2108/zsj.29.181
Received: 5 July 2011; Accepted: 1 October 2011; Published: 1 March 2012
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KEYWORDS
development
Endocrine
thyroxine (T4)
triiodothyronine (T3)
zebrafish
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