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1 March 2012 Collagen Reconstitution is Inversely Correlated with Induction of Limb Regeneration in Ambystoma mexicanum
Akira Satoh, Ayako Hirata, Aki Makanae
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Abstract

Amphibians can regenerate missing body parts, including limbs. The regulation of collagen has been considered to be important in limb regeneration. Collagen deposition is suppressed during limb regeneration, so we investigated collagen deposition and apical epithelial cap (AEC) formation during axolotl limb regeneration. The accessory limb model (ALM) has been developed as an alternative model for studying limb regeneration. Using this model, we investigated the relationship between nerves, epidermis, and collagen deposition. We found that Sp-9, an AEC marker gene, was upregulated by direct interaction between nerves and epidermis. However, collagen deposition hindered this interaction, and resulted in the failure of limb regeneration. During wound healing, an increase in deposition of collagen caused a decrease in the blastema induction rate in ALM. Wound healing and limb regeneration are alternate processes.

© 2012 Zoological Society of Japan
Akira Satoh, Ayako Hirata, and Aki Makanae "Collagen Reconstitution is Inversely Correlated with Induction of Limb Regeneration in Ambystoma mexicanum," Zoological Science 29(3), 191-197, (1 March 2012). https://doi.org/10.2108/zsj.29.191
Received: 1 July 2011; Accepted: 1 September 2011; Published: 1 March 2012
JOURNAL ARTICLE
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KEYWORDS
accessory limb model
Collagen
epidermis
limb regeneration
nerve
Sp-9
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