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1 October 2013 Evolutionary Aspects of Variability in bHLH Orthologous Families: Insights from the Pearl Oyster, Pinctada fucata
Fuki Gyoja, Nori Satoh
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Abstract

Basic helix-loop-helix (bHLH) transcription factors play significant roles in multiple biological processes in metazoan cells. In recent work, we showed that three orthologous HLH families, pearl, amber, and peridot, have apparently been lost in the Drosophila melanogaster, Caenorhabditis elegans, and Homo sapiens lineages. To further address the gain and loss of bHLH proteins during bilaterian evolution, we examined the genome of the pearl oyster, Pinctada fucata, which has recently been sequenced. We characterized the putative full set 65 bHLH genes and showed that genes previously categorized into the orthologous family PTFb, actually fall into two distinct orthologous families, 48-related-1 and 48-related-2. We also identified a novel orthologous family, clockwork orange. Based on these newly identified orthologous family members and on orphan bHLH factors, we propose that genes encoding bHLH factors in bilaterians are not as evolutionarily stable as previously thought.

© 2013 Zoological Society of Japan
Fuki Gyoja and Nori Satoh "Evolutionary Aspects of Variability in bHLH Orthologous Families: Insights from the Pearl Oyster, Pinctada fucata," Zoological Science 30(10), 868-876, (1 October 2013). https://doi.org/10.2108/zsj.30.868
Received: 5 November 2012; Accepted: 1 December 2012; Published: 1 October 2013
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KEYWORDS
evolution of orthologous families
genes for basic helix-loop-helix proteins
genomewide survey
Mollusca
Pinctada fucata
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