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1 July 2013 Release of Relaxin-Like Gonad-Stimulating Substance from Starfish Radial Nerves by lonomycin
Masatoshi Mita
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Abstract

In starfish, the peptide hormone gonad-stimulating substance (GSS) secreted from nervous tissue stimulates oocyte maturation to induce 1-methyladenine (1-MeAde) production by ovarian follicle cells. Recently, GSS was purified from radial nerves of the starfish Asterina pectinifera and identified as a relaxin-like peptide. This study examines the mechanism of GSS secretion from radial nerves. When radial nerves isolated from A. pectinifera were incubated in artificial seawater containing ionomycin as a calcium ionophore, GSS release increased in a dose-dependent manner; 50% activity of GSS release was obtained with approximately 10 µM ionomycin. Another calcium ionophore, A23187, also stimulated GSS release from radial nerves. In contrast, membrane permeable cyclic AMP and cyclic GMP analogs failed to induce GSS release. These results suggest that GSS secretion is induced by intracellular Ca2 as a second messenger.

© 2013 Zoological Society of Japan
Masatoshi Mita "Release of Relaxin-Like Gonad-Stimulating Substance from Starfish Radial Nerves by lonomycin," Zoological Science 30(7), 602-606, (1 July 2013). https://doi.org/10.2108/zsj.30.602
Received: 18 January 2013; Accepted: 1 February 2013; Published: 1 July 2013
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