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3 April 2020 Species-Dependent Enhancement of Ovarian Cancer G Protein-Coupled Receptor 1 Activation by Ogerin
Syo Murakami, Yuta Mochimaru, Shiori Musha, Ryotaro Kojima, Masahito Deai, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, Hideaki Tomura
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Abstract

Ogerin is a positive allosteric modulator of human and mouse ovarian cancer G protein-coupled receptors (OGR1s). In the present study, we found that ogerin differentially enhances the activation of OGR1 in various animal species. Amino acid residues of OGR1 that are associated with ogerin are conserved among the species. This suggests that other amino acid residues may be involved in the action of ogerin. Chimeric receptors between human and zebrafish OGR1s showed that the amino acid residues that determine the species specificity of ogerin-induced enhancement reside in the transmembrane and/or intracellular regions of OGR1. This result highlights the importance of first verifying the effectiveness of ogerin to the OGR1 of the species of interest at the cellular level prior to analyzing the physiological and pathophysiological roles of OGR1 in the species.

© 2020 Zoological Society of Japan 1
Syo Murakami, Yuta Mochimaru, Shiori Musha, Ryotaro Kojima, Masahito Deai, Chihiro Mogi, Koichi Sato, Fumikazu Okajima, and Hideaki Tomura "Species-Dependent Enhancement of Ovarian Cancer G Protein-Coupled Receptor 1 Activation by Ogerin," Zoological Science 37(2), 103-108, (3 April 2020). https://doi.org/10.2108/zs190106
Received: 13 August 2019; Accepted: 17 November 2019; Published: 3 April 2020
KEYWORDS
chimeric receptor
CRE-promoter
ogerin
ovarian cancer G protein-coupled receptor
positive allosteric modulator
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