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3 March 2023 Teratorn and Its Related Elements – a Novel Group of Herpesviruses Widespread in Teleost Genomes
Yusuke Inoue, Hiroyuki Takeda
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Abstract

Herpesviruses are a large family of DNA viruses infecting vertebrates and invertebrates, and are important pathogens in the field of aquaculture. In general, herpesviruses do not have the ability to integrate into the host genomes since they do not have a chromosomal integration step in their life cycles. Recently, we identified a novel group of herpesviruses, “Teratorn” and its related elements, in the genomes of various teleost fish species. At least some of the Teratorn-like herpesviruses are fused with a piggyBac-like DNA transposon, suggesting that they have acquired the transposon-like intragenomic lifestyle by hijacking the transposon system. In this review, we describe the sequence characteristics of Teratorn-like herpesviruses and phylogenetic relationships with other herpesviruses. Then we discuss the process of transposon-herpesvirus fusion, their life cycle, and the generality of transposon-virus fusion. Teratorn-like herpesviruses provide a piece of concrete evidence that even non-retroviral elements can become intragenomic parasites retaining replication capacity, by acquiring transposition machinery from other sources.

© 2023 Zoological Society of Japan
Yusuke Inoue and Hiroyuki Takeda "Teratorn and Its Related Elements – a Novel Group of Herpesviruses Widespread in Teleost Genomes," Zoological Science 40(2), 83-90, (3 March 2023). https://doi.org/10.2108/zs220069
Received: 28 August 2022; Accepted: 12 December 2022; Published: 3 March 2023
KEYWORDS
endogenous viral element
herpesvirus
medaka
piggyBac
teleost
transposable element
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