Nine new species of Muricidae from Guadeloupe, mainly collected during the 2012 KARUBENTHOS expedition, are described. Typhinellus lamyi n. sp. is compared with the similar species T. labiatus (Cristofori & Jan, 1832) from the Mediterranean Sea and T. occlusus (Garrard, 1963) from the Philippines. Dermomurex (Trialatella) pruvosti n. sp., D. (T.) boucheti n. sp., D. (T.) fajouensis n. sp. and D. (T.) tararensis n. sp. are compared with D. abyssicola (Crosse, 1865) occurring in the same area and with D. (T.) oxum Petuch, 1979 which ranges from Panama to Brazil. Pygmaepterys pointieri n. sp. and P. karukerensis n. sp. are compared with P. germainae Vokes & D'Attilio, 1980 and P. aliceae (Petuch, 1987). Muricopsis guadalupensis n. sp. is compared with M. caribbaea (Bartsch & Rehder, 1939) occurring throughout the Tropical West Atlantic and to M. marcusi Vokes, 1994 from Brazil. Lindapterys domlamyi n. sp. is compared with L. sanderi Petuch, 1987 from Barbados and Brazil and to the type species of the genus, L. vokesae Petuch, 1987 from the Early Miocene of Florida (USA). The name Murex hexagonus Lamarck, 1816, usually considered to be a primary homonym of Murex hexagonus (Gmelin, 1791), is rehabilitated (article 23.9.5, ICZN 1999). A lectotype of this species, is designated from the two syntypes housed in the MNHNG. Murex hexagonus is compared with other related Murexsul from the Caribbean area including M. oxytatus (Smith, 1938), M. zylmanae (Petuch, 1993), M. huberti (Radwin & D'Attilio, 1976), M. chesleri Houart, 2006, M. sunderlandi (Petuch, 1987), M. warreni (Petuch, 1993) and M. jahami Merle & Garrigues, 2011.