Platelet-activating factor (PAF) is a potent proinflammatory negotiator that shows a distinct spectrum of biological and pharmacological effects and participates in a wide range of pathophysiological conditions. In the reproductive system, PAF has been shown to have an important role in initiating ovulation, progesterone production and chemokine production. The purpose of this article was to review the roles of PAF, a well-known family of messenger phospholipids, in the reproductive process, especially in ovulation. This review highlights the interesting parallels between PAF's mechanism in ovulation and inflammatory process.
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1 October 2017
Inflammatory Mediators in Ovarian Follicles: The Possible Role of Platelet-Activating Factor and its Metabolic Enzyme
Yasushi Kawano,
Emi Harada,
Yuki Yamashita,
Yui Itonaga,
Naomi Inoue,
Hisashi Narahara
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chemokine
granulosa cells
ovulation
PAF-acetylhydrolase
platelet-activating factor