Orthogonikleithrus francogalliensis sp. nov., a new species of the family Orthogonikleithridae from the Late Jurassic Plattenkalks of Cerin (Ain, France), is described. The specimens were collected during excavations in Cerin by the Université Claude Bernard, Lyon. The fish were not immediately identified as new taxa but only in the framework of a current study on the temporal and spatial distribution of orthogonikleithrid fishes. The new species is superficially similar to Orthogonikleithrus hoelli but differs in several anatomical features, such as the presence of teeth, the number of tubules in the cephalic lateral line system, and the number of hypurals and uroneurals. Furthermore, due to the record of the genus Orthogonikleithrus in Cerin, the spatial distribution of this genus is extended, because it formerly was only known from Zandt and Ettling (both Bavaria, Germany).