Represented by a nearly complete cranium with associated mandible, teeth, and vertebrae, Yaquinacetus meadi is a new genus and species of archaic homodont odontocete from the latest Oligocene–early Miocene (24–19.2 Ma) of Oregon, U.S.A. The new species is characterized by a moderately elongated rostrum bearing approximately 51 alveoli per tooth row and a knob-like, rectangular vertex. Together with Squaloziphius emlongi from the early Miocene of Washington State, Y. meadi constitutes a new odontocete family, Squaloziphiidae, fam. nov., diagnosed by a unique combination of characters, including transversely wide dorsal opening of the mesorostral groove at base of rostrum, followed posteriorly by an abrupt narrowing; thickened lateral margin of the maxilla in the antorbital region making a long and laterally concave crest; and massive, anteroposteriorly and ventrally long postglenoid process of the squamosal. Although sharing with Ziphiidae the presence of transverse premaxillary crests on the vertex, Squaloziphiidae differs in the pterygoid sinus fossa being shorter anteriorly and ventrally; the tubercule of the malleus being less reduced; and lacking a pair of enlarged alveoli for mandibular tusks. Our phylogenetic analysis confirms the sister-group relationship between S. emlongi and Y. meadi, either as late diverging stem odontocetes or as early crown odontocetes, but distant from Ziphiidae. These results confirm the northeastern Pacific as a center of diversification for several groups of archaic homodont odontocetes during the late Oligocene–early Miocene.