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20 May 2019 Americium Systemic Biokinetic Model for Rats
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Abstract

In this work, a baseline compartmental model of the distribution and retention of americium in the rat for a systemic intake was derived. The model was derived from data obtained from a study designed to evaluate the behavior of americium in the first 28 days after incorporation. A pharmacokinetic (PK)-front-end modeling approach was used to specify transfer to and from the extracellular fluids (ECF) in the various tissues in terms of vascular flow and volumes of ECF. Back-end rates representing transport into and out of the cells were determined empirically. Uncertainties in transfer rates were investigated using Markov chain Monte Carlo (MCMC). The combination of PK-front-end model and the back-end model structure used allowed for extrapolation to the earliest times with small uncertainty. This approach clearly demonstrated the rapid transfer of material from ECF to liver and bone. This model provides a baseline for modeling the action of decorporation agents, such as DTPA.

©2019 by Radiation Research Society. All rights of reproduction in any form reserved.
Guthrie Miller, John A. Klumpp, Deepesh Poudel, Waylon Weber, Raymond A. Guilmette, Jasen Swanson, and Dunstanta R. Melo "Americium Systemic Biokinetic Model for Rats," Radiation Research 192(1), 75-91, (20 May 2019). https://doi.org/10.1667/RR15256.1
Received: 1 October 2018; Accepted: 18 April 2019; Published: 20 May 2019
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