A new species Uvaria rovumae Deroin & Lötter, sp. nov. is described, illustrated and mapped from Cabo Delgado Province in northern Mozambique. Its morphology, as well as systematic affinities, habitat and conservation status are briefly discussed. Very similar to U. tanzaniae Verdc. by its habit, it differs mainly by its free sepals, inner petals slightly unguiculate and a high carpel number (>35). Uvaria rovumae Deroin & Lötter, sp. nov. is known only from a handful of individual plants in one location near Nangade, making it “Critically Endangered” (CR) following IUCN Red List categories and criteria.