Haematoporphyrin efficiency on Aedes caspius increased the larval mortality with the increase of haematoporphyrin formulation (HPF) concentration (1 × 10³ M/l). Larval mortality increased with increase the solar simulator light irradiances (350–650 W/m²) and exposure times (45 min). Dynamics of HPF accumulation and release as a function of time feeding and consumption was investigated using confocal laser scanning microscopy (CLSM). HPF accumulation in the larval body reached its maximum level after incubation for 12 h. Remaining HPF concentration decreased as the time elapsed reaching its minimal level after 15 h of HPF removal from the treatment medium.