Twelve new and noteworthy fern taxa consisting of one North American record for a non-native species (Dryopteris hangchowensis), one native species state record (Asplenium heteroresiliens), four non-native species state records (Anisocampium niponicum, Ceratopteris aff. thalictroides, Lygodium microphyllum, and Pteris quadriaurita), three noteworthy native species (Crepidomanes intricatum, Dryopteris australis, and Vandenboschia boschiana), and three naturally occurring hybrids (Asplenium ×gravesii, Asplenium ×kentuckiense, and Asplenium ×trudellii) of interest are reported and described herein as significant additions to the flora of Alabama.