The terrestrial slug Deroceras reticulatum (Müller 1744) was used to examine if memory disruption could be restored by hormetic interventions. Hormesis is the process by which a potentially harmful stimulus elicits beneficial effects in the correct dosage and duration. From single-trial aversive stimulus conditioning, memory retention factor (Rf) was used to assess the effects of conditioning and oxidative damage via H₂O₂-injection at one day (Rf₁) and seven days (Rf₇), representing short- and long-term responses, respectively. Results from the conditioning showed a significant increase in Rf₁ in the experimental group compared to the control but not Rf₇. The induction of an oxidatively damaged phenotype was supported with significantly decreased Rf₁ in H₂O₂ injected-slugs compared to the saline-injected control. Calorie restriction (CR) and heat stress (HS) have been shown to extend lifespan in model systems, and they are thought to act, in part, through a hormetic mechanism. However, to our knowledge, the combination of both CR and HS has yet to be explored in the context of a systems-level assay, such as memory retention. HS and CR administered independently did not confer significant protection/recovery from oxidative damage. Co-administration of HS and CR similarly failed to offer significant protection/recovery from oxidative damage. Consequently, wild-caught phenotypically diverse terrestrial slugs used in the current study were susceptible to short-term conditioning (Rf₁), but not long-term conditioning (Rf₇), and oxidative damage from H₂O₂ was shown to disrupt memory. However, HS and CR had only a weak, non-significant effect on improving the disrupted memory phenotype.