The phylogenetic position and taxonomic status of the monotypic genus Lappodochium Matsush. and its constituent species Lappodochium lageniforme Matsush. have long been uncertain. A multilocus phylogenetic analysis of combined ITS, LSU, rpb2 and tub2 datasets and morphological data were used to establish relationships of Lappodochium lageniforme within the Chaetomiaceae. Phylogenetic analyses revealed a strongly supported monophyletic clade of Lappodochium lageniforme with Botryoderma strains. These results provide sufficient data to re-examine the phylogenetic position of Lappodochium and propose the new combination Botryoderma lageniforme (Matsush.) Gusmão, G.G.Barreto & M.G.A.Primo. The previously invalidly published B. rostratum is also validated, as B. rostratum Papendorf & H.P.Upadhyay ex Gusmão & G.G.Barreto. We also provide a key and synopsis of all accepted Botryoderma species.