Standardization of an Inactivated H7N1 Avian Influenza Vaccine and Efficacy Against A/Chicken/Italy/13474/99 High-Pathogenicity Virus Infection

L. Di Trani; P. Cordioli; E. Falcone; G. Lombardi; A. Moreno; G. Sala; M. Tollis

doi:10.1637/0005-2086-47.s3.1042

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1 September 2003 Standardization of an Inactivated H7N1 Avian Influenza Vaccine and Efficacy Against A/Chicken/Italy/13474/99 High-Pathogenicity Virus Infection

L. Di Trani, P. Cordioli, E. Falcone, G. Lombardi, A. Moreno, G. Sala, M. Tollis

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Avian Diseases, 47(s3):1042-1046 (2003). https://doi.org/10.1637/0005-2086-47.s3.1042

Abstract

The minimum requirements for assessing the immunogenicity of an experimental avian influenza (AI) vaccine prepared from inactivated A/Turkey/Italy/2676/99 (H7N1) low-pathogenicity (LP) AI (LPAI) virus were determined in chickens of different ages. A correlation between the amount of hemagglutinin (HA) per dose of vaccine and the protection against clinical signs of disease and infection by A/Chicken/Italy/13474/99 highly pathogenic (HP) AI (HPAI) virus was established. Depending on the vaccination schedule, one or two administrations of 0.5 μg of hemagglutinin protected chickens against clinical signs and death and completely prevented virus shedding from birds challenged at different times after vaccination.

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L. Di Trani, P. Cordioli, E. Falcone, G. Lombardi, A. Moreno, G. Sala, and M. Tollis "Standardization of an Inactivated H7N1 Avian Influenza Vaccine and Efficacy Against A/Chicken/Italy/13474/99 High-Pathogenicity Virus Infection," Avian Diseases 47(s3), 1042-1046, (1 September 2003). https://doi.org/10.1637/0005-2086-47.s3.1042

Received: 14 April 2002; Published: 1 September 2003

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