Meiotic Nondisjunction of Chromosomes 1, 17, 18, X, and Y in Men More Than 80 Years of Age

M. Guttenbach; F-M. Köhn; W. Engel; M. Schmid

doi:10.1095/biolreprod63.6.1727

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M. Guttenbach,¹ F-M. Köhn,² W. Engel,³ M. Schmid^1,*

¹aInstitut für Humangenetik, Universität Würzburg, Biozentrum, Am Hubland, 97074 Würzburg, Germany
²bKlinik und Poliklinik für Dermatologie und Allergologie, 80802 München, Germany
³cInstitut für Humangenetik, Universität Göttingen, 37073 Göttingen, Germany

^*Correspondence: Michael Schmid, Department of Human Genetics, University of Würzburg, Biozentrum, Am Hubland, 97074 Würzburg, Germany. FAX: 49 931 8884069; m.schmid@biozentrum.uni-wuerzburg.de

Abstract

In order to evaluate a possible paternal age effect, testicular sperm cells from three men aged 81, 82, and 83 yr were analyzed by two-color- and three-color-fluorescence in situ hybridization for disomy rates of chromosomes 1, 17, 18, X, and Y as well as for diploidy frequencies. A minimum of 1500 sperm cells per donor and probe was evaluated due to the low number of spermatozoa in the preparations. Diploidy and disomy frequencies were in the same range as found in men aged <30 yr, a slight increase only being noticed for XY nuclei.

Citation Download Citation

M. Guttenbach, F-M. Köhn, W. Engel, and M. Schmid "Meiotic Nondisjunction of Chromosomes 1, 17, 18, X, and Y in Men More Than 80 Years of Age," Biology of Reproduction 63(6), 1727-1729, (1 December 2000). https://doi.org/10.1095/biolreprod63.6.1727

Received: 7 October 1999; Accepted: 1 July 2000; Published: 1 December 2000

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