Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice1

Chenling Meng; Wenjing Liu; Huihui Huang; Yang Wang; Binbin Chen; Gordon J. Freeman; Alan Schneyer; Herbert Y. Lin; Yin Xia

doi:10.1095/biolreprod.115.135921

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24 February 2016 Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice

Chenling Meng, Wenjing Liu, Huihui Huang, Yang Wang, Binbin Chen, Gordon J. Freeman, Alan Schneyer, Herbert Y. Lin, Yin Xia

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Biology of Reproduction, 94(4): (2016). https://doi.org/10.1095/biolreprod.115.135921

Abstract

Bone morphogenetic protein (BMP) signaling plays an important role in spermatogenesis and follicle development. Our previous studies have shown that repulsive guidance molecule b (RGMb, also known as Dragon) is a coreceptor that enhances BMP2 and BMP4 signaling in several cell types and that RGMb is expressed in spermatocytes and spermatids in the testis and in oocytes of the secondary follicles in the ovary. Here, we demonstrated that specific deletion of Rgmb in germ cells in the testis and ovary did not alter Smad1/5/8 phosphorylation, gonadal structures, and fertility. In addition, ovaries from postnatal global Rgmb knockout mice showed similar structures to the wild-type ovaries. Our results suggest that RGMb is not essential for normal gonadal function.

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Chenling Meng, Wenjing Liu, Huihui Huang, Yang Wang, Binbin Chen, Gordon J. Freeman, Alan Schneyer, Herbert Y. Lin, and Yin Xia "Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice," Biology of Reproduction 94(4), (24 February 2016). https://doi.org/10.1095/biolreprod.115.135921

Received: 1 October 2015; Accepted: 1 February 2016; Published: 24 February 2016

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