The effects of the Echinacea on superoxide anion production by the promyelocytic cell line, HL-60, were evaluated by culturing the cells with a 55% ethanol extract of the aerial parts of Echinacea purpurea. HL-60 cells cultured with the 55% ethanol extract of E. purpurea alone at 28 µg/ml produced statistically significant levels of superoxide anion compared to vehicle-treated controls (p < 0.05). These data suggest that the 55% ethanol extract of E. purpurea contains immunomodulatory compounds capable of stimulating superoxide anion production by HL-60 cells; and, as such, may have implications for therapeutic use.
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13 March 2023
The effects of a 55% ethanol extract of Echinacea purpurea on superoxide anion production by HL-60 cells
Brian J. Merkel,
Julie Wondergem,
Dhanamalee Bandara,
Jessica Stolfi,
Lauren Caruso,
Ben Gilles,
Brady Sarauer,
Zachary Holcomb,
Stephanie Bialcik
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BIOS
Vol. 94 • No. 1
March 2023
Vol. 94 • No. 1
March 2023
neutrophils