Pachyphytum huastecanum is described as a new species discovered in the Cañón de la Huasteca in the Sierra Madre Oriental in the Mexican state of Nuevo León. This species is placed in section Diotostemon, where it is morphologically related to Pachyphytum hookeri, from which it differs by its shorter stems, compact rosettes, flat, olive-green colored leaves, shorter pedicels, its campanulate flowers and obovate petals. Additionally, two DNA diagnostic nucleotides were found at the ITS2 nuclear genome region which differentiate the new species from other 19 Pachyphytum species.