The effect of trenbolone acetate + estradiol (TBA) implants, melengestrol acetate (MGA), and ractopamine hydrochloride + TBA (RAC + TBA) on growth performance and carcass characteristics in beef cattle (n = 680; 279 ± 10.1 kg) fed barley grain/corn silage was examined in a 4 yr study (four pens per treatment per year; 262 ± 8 d feeding period). In the first 2 yr, treatments were (1) control heifers (H-CON; no growth promoters), (2) TBA-implanted heifers (H-TBA), (3) MGA heifers (H-MGA), (4) control steers (S-CON; no growth promoters), and (5) TBA-implanted steers (S-TBA). A sixth treatment (6) RAC + TBA steers (RAC + TBA) was included in years 3 and 4. Overall dry matter intake (DMI) of heifers was increased (P < 0.001) by TBA but not MGA. Compared with H-CONs, H-TBA had greater average daily gain (ADG) (P < 0.001), gain to feed ratio (G/F) (P < 0.001), and carcass weight (P < 0.001), whereas S-TBA had increased ADG (P < 0.001), G/F (P< 0.001), and carcass weight (P < 0.001) compared with S-CON. Compared with H-CON, H-MGA had increased (P < 0.01) ADG, G/F, and carcass weight. The RAC + TBA had increased (P < 0.01) ADG and carcass weight (3.2%) but not G/F or DMI compared with S-TBA. This 4 yr study showed a consistent positive impact of growth-enhancing technologies on the performance of Canadian feedlot cattle.