This study evaluated the efficacy of extracted rice bran (ERB) in weanling piglets. One hundred forty weanling pigs [(Yorkshire × Landrace) × Duroc] with an average BW of 5.70 ± 1.41 kg (21 d of age) were fed in two phases in a 6-wk experiment. Weanling pigs were allotted to diets containing 0 or 0.1 g kg⁻¹ of ERB, and 0 or 165 mg kg⁻¹ of apramycin according to a 2 × 2 factorial arrangement of treatments. Both apramycin and ERB supplementation increased growth efficiency (G:F) during phase 1 and overall, respectively (P < 0.05). The apparent total tract digestibility (ATTD) of dry matter (DM) was increased in response to either ERB or apramycin at wk 2 and 6 (P < 0.05). Supplementation of ERB decreased total cholesterol (TC) and increased high-density lipoprotein cholesterol (HDL-C) in diets lacking ERB at wk 6 (P < 0.05). Pigs receiving diets supplemented with apramycin reduced Escherichia coli at wk 2 and 6, and Salmonella counts at wk 6 (P < 0.05). Supplementation of ERB increased fecal Lactobacillus and reduced Salmonella counts at wk 6 (P < 0.05). In conclusion, results indicated that dietary supplementation of ERB improved performance in weanling pigs.