This paper evaluates the bioavailability of allium derivative propyl propane thiosulfonate (PTSO) in the pig gastrointestinal tract by means of an in vitro dynamic gastrointestinal tract simulator system (GITSS). The GITSS is based on a membrane bioreactor comprising a continuous stirred-tank reactor connected in series to a continuous plug-flow tubular reactor. Bioavailability values have been evaluated for different vehiculization strategies, including mere carriers such as polyethylene glycol sorbitan monooleate (a nonionic surfactant also known as Tween 80) and encapsulation matrices (β-cyclodextrin vs. mono- and di-glycerides of edible fatty acids mixed with hydrogenated sunflower oil) and compared with the absorption of free PTSO. The net absorbed amount of PTSO in the GITSS when Tween 80 was used as a carrier was over 3.5 times higher than the one for free PTSO. Neither the encapsulated PTSO in β-cyclodextrin nor by means of mono- and di-glycerides of fatty acids plus a vegetable oil succeeded to improve absorption values for free PTSO. These promising results indicate that Tween 80 provides an interesting and high resistance to the PTSO molecule against the simulated digestive conditions in the stomach, and thus it enables favorably the subsequent absorption process of PTSO along the intestine.
How to translate text using browser tools
28 August 2018
Effects of different vehiculization strategies for the allium derivative propyl propane thiosulfonate during dynamic simulation of the pig gastrointestinal tract
Paloma Abad,
Natalia Arroyo-Manzanares,
E. Rivas-Montoya,
J.M. Ochando-Pulido,
Enrique Guillamon,
Ana M. García-Campaña,
Antonio Martinez-Ferez
ACCESS THE FULL ARTICLE
It is not available for individual sale.
This article is only available to subscribers.
It is not available for individual sale.
It is not available for individual sale.
Canadian Journal of Animal Science
Vol. 99 • No. 2
June 2019
Vol. 99 • No. 2
June 2019
bioavailability
gastrointestinal tract simulation
pig digestion
propyl propane thiosulfonate (PTSO)