Byker, H. P., Soltani, N., Robinson, D. E., Tardif, F. J., Lawton, M. B. and Sikkema, P. H. 2013. Glyphosate-resistant Canada fleabane [Conyza canadensis(L). Cronq.]: Dose response to glyphosate and control with postemergence herbicides in soybean in Ontario. Can. J. Plant Sci. 93: 1187-1193. Glyphosate-resistant (GR) Canada fleabane was first reported in Ontario in 2010. Twelve field studies were conducted over a 2-yr period (2011, 2012) to determine the biologically effective dose of glyphosate in the field and to determine the efficacy of postemergence herbicides for control of GR Canada fleabane. A dose between 1271 and 5652 g a.e. ha^-1 was required for a 50% reduction in Canada fleabane biomass depending on site and year. To achieve acceptable (>95%) control with glyphosate, 18 840 to 43 200 g a.e. ha^-1 of glyphosate was required across all sites. Therefore application of glyphosate at these doses for acceptable (>95%) control is not economical. None of the postemergence herbicides labeled for use in soybean provided acceptable (>95%) control, with cloransulam providing the greatest control (67%) 4 wk after application. Therefore, GR Canada fleabane must be controlled prior to soybean emergence as current herbicides registered in soybean for postemergence use do not provide sufficient control to prevent soybean yield loss.