With no new herbicides with a novel mode of action in the marketplace in corn–soybean cropping systems, control of glyphosate-resistant (GR) weeds requires the re-evaluation of existing herbicides. This necessitates a renewed focus on using herbicide tank-mixes and sequential herbicide programs while also striving to minimize the environmental impact of weed management. Preliminary research identified four preplant (PP) herbicides (2,4-D, saflufenacil/dimethenamid-P, linuron, and metribuzin) and one postemergence (POST) herbicide (fomesafen) that provided good but inconsistent control of GR common ragweed when applied alone in soybean. The objectives of this study were to determine the biologically effective rate of metribuzin and evaluate PP followed by POST herbicide programs for control of GR common ragweed in soybean. The aforementioned PP herbicides reduced GR common ragweed density and aboveground biomass by 82%–94% and 55%–89%, respectively. In contrast, a PP herbicide followed by fomesafen applied POST decreased common ragweed densities and aboveground biomass by 97%–99% and 93%–98%, respectively. Metribuzin applied at 824 and 1015 g a.i. ha^-1 controlled GR common ragweed 90% at 4 and 8 wk after application, respectively. This study concludes that GR common ragweed can be controlled with a PP followed by POST herbicide program and metribuzin has potential for control of GR common ragweed in soybean.