Eight species of polychrotid lizard have been recorded from the Venezuelan Coastal Range. Among them, Anolis squamulatus and A. tigrinus are two of the most distinctive due to their size (the first one very large, the latter very small). However, very little is known about their morphological variation, coloration in life, and biology. Detailed descriptions of A. squamulatus and A. tigrinus are presented based on previously and newly collected material. Color variation, sexual dichromatism and natural habits of both taxa are also documented. Habitat partitioning among the polychrotid lizards sympatric with A. squamulatus and A. tigrinus is also discussed.