Salmonella Typhimurium, a zoonotic and foodborne pathogen, has experienced a surge in antibiotic resistance, contributing to a global public health crisis. In response to this crisis, the isolation and studying of bacteriophages has gained significance as an alternative biological control and/or treatment modalities in combating these bacterial pathogens. This study reports the isolation of Salmonella bacteriophages from wastewater at the treatment plant in Mayagüez, Puerto Rico. MBBL_B and MBBL_S, two Salmonella Typhimurium bacteriophages, were isolated and their host range was tested against eight serovars. The results showcase two isolated bacteriophages from the class Caudoviricetes with the ability to infect various serovars of Salmonella enterica subsp. enterica, including Typhimurium, Tennessee, Lexington, Havana, and Heidelberg, highlighting the potential use of bacteriophages for biocontrol of foodborne pathogens.